There are
2,846 mi
from San Mateo, CA to Titusville, FL
That's the driving distance. It would take 2 days 3 hours to go from San Mateo, California to Titusville, Florida.
The flight distance (direct flight from San Mateo, CA to Titusville, FL) is 2,460.56 mi.
2,846 mi = 3.22 kms