There are
2,113 mi
from San Mateo, CA to St Charles, IL
That's the driving distance. It would take 1 day 12 hours to go from San Mateo, California to St Charles, Illinois.
The flight distance (direct flight from San Mateo, CA to St Charles, IL) is 1,819.81 mi.
2,113 mi = 3,400.84 kms