There are
2,865 mi
from San Mateo, CA to Smithfield, NC
That's the driving distance. It would take 2 days 3 hours to go from San Mateo, California to Smithfield, North Carolina.
The flight distance (direct flight from San Mateo, CA to Smithfield, NC) is 2,423.72 mi.
2,865 mi = 3.22 kms