There are
2,617 mi
from San Mateo, CA to Simpsonville, SC
That's the driving distance. It would take 1 day 22 hours to go from San Mateo, California to Simpsonville, South Carolina.
The flight distance (direct flight from San Mateo, CA to Simpsonville, SC) is 2,227.29 mi.
2,617 mi = 3.22 kms