There are
2,134 mi
from San Mateo, CA to Sikeston, MO
That's the driving distance. It would take 1 day 14 hours to go from San Mateo, California to Sikeston, Missouri.
The flight distance (direct flight from San Mateo, CA to Sikeston, MO) is 1,792.72 mi.
2,134 mi = 3.22 kms