There are
2,808 mi
from San Mateo, CA to Sanford, FL
That's the driving distance. It would take 2 days 3 hours to go from San Mateo, California to Sanford, Florida.
The flight distance (direct flight from San Mateo, CA to Sanford, FL) is 2,429.58 mi.
2,808 mi = 3.22 kms