There are
2,727 mi
from San Mateo, CA to Roanoke, VA
That's the driving distance. It would take 2 days to go from San Mateo, California to Roanoke, Virginia.
The flight distance (direct flight from San Mateo, CA to Roanoke, VA) is 2,305.77 mi.
2,727 mi = 4,388.48 kms