There are
348 mi
from San Mateo, CA to Port Hueneme, CA
That's the driving distance. It would take 6 hours 57 mins to go from San Mateo, California to Port Hueneme, California.
The flight distance (direct flight from San Mateo, CA to Port Hueneme, CA) is 293.93 mi.
348 mi = 559.26 kms