There are
2,286 mi
from San Mateo, CA to Picayune, MS
That's the driving distance. It would take 1 day 16 hours to go from San Mateo, California to Picayune, Mississippi.
The flight distance (direct flight from San Mateo, CA to Picayune, MS) is 1,920.71 mi.
2,286 mi = 3.22 kms