There are
2,490 mi
from San Mateo, CA to Panama City, FL
That's the driving distance. It would take 1 day 20 hours to go from San Mateo, California to Panama City, Florida.
The flight distance (direct flight from San Mateo, CA to Panama City, FL) is 2,150.49 mi.
2,490 mi = 4,006.81 kms