There are
2,725 mi
from San Mateo, CA to Palatka, FL
That's the driving distance. It would take 2 days 1 hour to go from San Mateo, California to Palatka, Florida.
The flight distance (direct flight from San Mateo, CA to Palatka, FL) is 2,384.99 mi.
2,725 mi = 4,386.22 kms