There are
2,688 mi
from San Mateo, CA to Orangeburg, SC
That's the driving distance. It would take 1 day 23 hours to go from San Mateo, California to Orangeburg, South Carolina.
The flight distance (direct flight from San Mateo, CA to Orangeburg, SC) is 2,329.94 mi.
2,688 mi = 3.22 kms