There are
2,425 mi
from San Mateo, CA to Opelika, AL
That's the driving distance. It would take 1 day 18 hours to go from San Mateo, California to Opelika, Alabama.
The flight distance (direct flight from San Mateo, CA to Opelika, AL) is 2,102.24 mi.
2,425 mi = 3,902.92 kms