There are
2,415 mi
from San Mateo, CA to Nicholasville, KY
That's the driving distance. It would take 1 day 18 hours to go from San Mateo, California to Nicholasville, Kentucky.
The flight distance (direct flight from San Mateo, CA to Nicholasville, KY) is 2,049.06 mi.
2,415 mi = 3.22 kms