There are
3,162 mi
from San Mateo, CA to Newburyport, MA
That's the driving distance. It would take 2 days 8 hours to go from San Mateo, California to Newburyport, Massachusetts.
The flight distance (direct flight from San Mateo, CA to Newburyport, MA) is 2,697.40 mi.
3,162 mi = 4.83 kms