There are
2,814 mi
from San Mateo, CA to New Smyrna Beach, FL
That's the driving distance. It would take 2 days 2 hours to go from San Mateo, California to New Smyrna Beach, Florida.
The flight distance (direct flight from San Mateo, CA to New Smyrna Beach, FL) is 2,441.83 mi.
2,814 mi = 4,528.02 kms