There are
2,098 mi
from San Mateo, CA to Natchez, MS
That's the driving distance. It would take 1 day 13 hours to go from San Mateo, California to Natchez, Mississippi.
The flight distance (direct flight from San Mateo, CA to Natchez, MS) is 1,798.98 mi.
2,098 mi = 3.22 kms