There are
2,377 mi
from San Mateo, CA to Middletown, OH
That's the driving distance. It would take 1 day 17 hours to go from San Mateo, California to Middletown, Ohio.
The flight distance (direct flight from San Mateo, CA to Middletown, OH) is 2,039.03 mi.
2,377 mi = 3.22 kms