There are
2,476 mi
from San Mateo, CA to Maryville, TN
That's the driving distance. It would take 1 day 19 hours to go from San Mateo, California to Maryville, Tennessee.
The flight distance (direct flight from San Mateo, CA to Maryville, TN) is 2,114.82 mi.
2,476 mi = 3.22 kms