There are
3,131 mi
from San Mateo, CA to Lowell, MA
That's the driving distance. It would take 2 days 7 hours to go from San Mateo, California to Lowell, Massachusetts.
The flight distance (direct flight from San Mateo, CA to Lowell, MA) is 2,677.67 mi.
3,131 mi = 4.83 kms