There are
2,125 mi
from San Mateo, CA to Lisle, IL
That's the driving distance. It would take 1 day 12 hours to go from San Mateo, California to Lisle, Illinois.
The flight distance (direct flight from San Mateo, CA to Lisle, IL) is 1,832.27 mi.
2,125 mi = 3.22 kms