There are
2,664 mi
from San Mateo, CA to Lexington, SC
That's the driving distance. It would take 1 day 23 hours to go from San Mateo, California to Lexington, South Carolina.
The flight distance (direct flight from San Mateo, CA to Lexington, SC) is 2,298.41 mi.
2,664 mi = 3.22 kms