There are
1,470 mi
from San Mateo, CA to Lexington, NE
That's the driving distance. It would take 1 day to go from San Mateo, California to Lexington, Nebraska.
The flight distance (direct flight from San Mateo, CA to Lexington, NE) is 1,226.45 mi.
1,470 mi = 1.61 kms