There are
2,413 mi
from San Mateo, CA to Lexington, KY
That's the driving distance. It would take 1 day 18 hours to go from San Mateo, California to Lexington, Kentucky.
The flight distance (direct flight from San Mateo, CA to Lexington, KY) is 2,050.64 mi.
2,413 mi = 3.22 kms