There are
2,819 mi
from San Mateo, CA to Lake Mary, FL
That's the driving distance. It would take 2 days 2 hours to go from San Mateo, California to Lake Mary, Florida.
The flight distance (direct flight from San Mateo, CA to Lake Mary, FL) is 2,428.28 mi.
2,819 mi = 4,536.76 kms