There are
2,046 mi
from San Mateo, CA to La Crosse, WI
That's the driving distance. It would take 1 day 11 hours to go from San Mateo, California to La Crosse, Wisconsin.
The flight distance (direct flight from San Mateo, CA to La Crosse, WI) is 1,674.02 mi.
2,046 mi = 3.22 kms