There are
2,469 mi
from San Mateo, CA to Knoxville, TN
That's the driving distance. It would take 1 day 19 hours to go from San Mateo, California to Knoxville, Tennessee.
The flight distance (direct flight from San Mateo, CA to Knoxville, TN) is 2,113.91 mi.
2,469 mi = 3,972.98 kms