There are
2,844 mi
from San Mateo, CA to Knightdale, NC
That's the driving distance. It would take 2 days 2 hours to go from San Mateo, California to Knightdale, North Carolina.
The flight distance (direct flight from San Mateo, CA to Knightdale, NC) is 2,410.65 mi.
2,844 mi = 4,576.56 kms