There are
372 mi
from San Mateo, CA to Klamath Falls, OR
That's the driving distance. It would take 7 hours 3 mins to go from San Mateo, California to Klamath Falls, Oregon.
The flight distance (direct flight from San Mateo, CA to Klamath Falls, OR) is 323.39 mi.
372 mi = 599.13 kms