There are
2,531 mi
from San Mateo, CA to Ironton, OH
That's the driving distance. It would take 1 day 20 hours to go from San Mateo, California to Ironton, Ohio.
The flight distance (direct flight from San Mateo, CA to Ironton, OH) is 2,141.13 mi.
2,531 mi = 3.22 kms