There are
2,321 mi
from San Mateo, CA to Hopkinsville, KY
That's the driving distance. It would take 1 day 16 hours to go from San Mateo, California to Hopkinsville, Kentucky.
The flight distance (direct flight from San Mateo, CA to Hopkinsville, KY) is 1,906.45 mi.
2,321 mi = 3.22 kms