There are
1,972 mi
from San Mateo, CA to Harlingen, TX
That's the driving distance. It would take 1 day 10 hours to go from San Mateo, California to Harlingen, Texas.
The flight distance (direct flight from San Mateo, CA to Harlingen, TX) is 1,637.62 mi.
1,972 mi = 1.61 kms