There are
2,615 mi
from San Mateo, CA to Greenwood, SC
That's the driving distance. It would take 1 day 22 hours to go from San Mateo, California to Greenwood, South Carolina.
The flight distance (direct flight from San Mateo, CA to Greenwood, SC) is 2,243.47 mi.
2,615 mi = 3.22 kms