There are
2,609 mi
from San Mateo, CA to Greenville, SC
That's the driving distance. It would take 1 day 22 hours to go from San Mateo, California to Greenville, South Carolina.
The flight distance (direct flight from San Mateo, CA to Greenville, SC) is 2,217.39 mi.
2,609 mi = 3.22 kms