There are
2,917 mi
from San Mateo, CA to Greenville, NC
That's the driving distance. It would take 2 days 3 hours to go from San Mateo, California to Greenville, North Carolina.
The flight distance (direct flight from San Mateo, CA to Greenville, NC) is 2,474.02 mi.
2,917 mi = 4,694.32 kms