There are
2,543 mi
from San Mateo, CA to Greeneville, TN
That's the driving distance. It would take 1 day 20 hours to go from San Mateo, California to Greeneville, Tennessee.
The flight distance (direct flight from San Mateo, CA to Greeneville, TN) is 2,169.27 mi.
2,543 mi = 3.22 kms