There are
2,694 mi
from San Mateo, CA to Gainesville, FL
That's the driving distance. It would take 2 days to go from San Mateo, California to Gainesville, Florida.
The flight distance (direct flight from San Mateo, CA to Gainesville, FL) is 2,347.28 mi.
2,694 mi = 4,334.79 kms