There are
2,741 mi
from San Mateo, CA to Fernandina Beach, FL
That's the driving distance. It would take 2 days 1 hour to go from San Mateo, California to Fernandina Beach, Florida.
The flight distance (direct flight from San Mateo, CA to Fernandina Beach, FL) is 2,366.40 mi.
2,741 mi = 3.22 kms