There are
2,134 mi
from San Mateo, CA to Farmington, MO
That's the driving distance. It would take 1 day 13 hours to go from San Mateo, California to Farmington, Missouri.
The flight distance (direct flight from San Mateo, CA to Farmington, MO) is 1,736.30 mi.
2,134 mi = 3.22 kms