There are
2,831 mi
from San Mateo, CA to Ephrata, PA
That's the driving distance. It would take 2 days 1 hour to go from San Mateo, California to Ephrata, Pennsylvania.
The flight distance (direct flight from San Mateo, CA to Ephrata, PA) is 2,461 mi.
2,831 mi = 3.22 kms