There are
1,727 mi
from San Mateo, CA to Desoto, TX
That's the driving distance. It would take 1 day 6 hours to go from San Mateo, California to Desoto, Texas.
The flight distance (direct flight from San Mateo, CA to Desoto, TX) is 1,475.62 mi.
1,727 mi = 2,779.48 kms