There are
2,339 mi
from San Mateo, CA to Clarksville, IN
That's the driving distance. It would take 1 day 16 hours to go from San Mateo, California to Clarksville, Indiana.
The flight distance (direct flight from San Mateo, CA to Clarksville, IN) is 1,980.31 mi.
2,339 mi = 3.22 kms