There are
2,094 mi
from San Mateo, CA to Clarksdale, MS
That's the driving distance. It would take 1 day 13 hours to go from San Mateo, California to Clarksdale, Mississippi.
The flight distance (direct flight from San Mateo, CA to Clarksdale, MS) is 1,784.27 mi.
2,094 mi = 3.22 kms