There are
2,457 mi
from San Mateo, CA to Chillicothe, OH
That's the driving distance. It would take 1 day 19 hours to go from San Mateo, California to Chillicothe, Ohio.
The flight distance (direct flight from San Mateo, CA to Chillicothe, OH) is 2,115.64 mi.
2,457 mi = 3.22 kms