There are
2,673 mi
from San Mateo, CA to Cayce, SC
That's the driving distance. It would take 1 day 23 hours to go from San Mateo, California to Cayce, South Carolina.
The flight distance (direct flight from San Mateo, CA to Cayce, SC) is 2,307.58 mi.
2,673 mi = 3.22 kms