There are
2,828 mi
from San Mateo, CA to Cary, NC
That's the driving distance. It would take 2 days 2 hours to go from San Mateo, California to Cary, North Carolina.
The flight distance (direct flight from San Mateo, CA to Cary, NC) is 2,394.40 mi.
2,828 mi = 4,551.62 kms