There are
2,179 mi
from San Mateo, CA to Cape Girardeau, MO
That's the driving distance. It would take 1 day 13 hours to go from San Mateo, California to Cape Girardeau, Missouri.
The flight distance (direct flight from San Mateo, CA to Cape Girardeau, MO) is 1,790.77 mi.
2,179 mi = 3.22 kms