There are
2,082 mi
from San Mateo, CA to Cahokia, IL
That's the driving distance. It would take 1 day 12 hours to go from San Mateo, California to Cahokia, Illinois.
The flight distance (direct flight from San Mateo, CA to Cahokia, IL) is 1,740.54 mi.
2,082 mi = 3.22 kms