There are
2,588 mi
from San Mateo, CA to Asheville, NC
That's the driving distance. It would take 1 day 22 hours to go from San Mateo, California to Asheville, North Carolina.
The flight distance (direct flight from San Mateo, CA to Asheville, NC) is 2,194.34 mi.
2,588 mi = 3.22 kms