There are
2,824 mi
from San Mateo, CA to Apex, NC
That's the driving distance. It would take 2 days 2 hours to go from San Mateo, California to Apex, North Carolina.
The flight distance (direct flight from San Mateo, CA to Apex, NC) is 2,391.81 mi.
2,824 mi = 4,544.65 kms